Collaborative work with Carmen Galan’s group has just been published in Angewandte Chemie. The paper details the synthesis of a stiff-stillbene ligand which induces conformational unfolding of G-quadruplex. Upon 400 nm irradiation this effect can be reversed via photooxidation of the ligand. Remarkably, the conformation of G4 DNA was switched 5 times.
Tom Swift has been awarded one of the University of Bristol’s prestigious EPSRC doctoral prize fellowships to work in the Oliver group. The prize provides 2 years of post-doctoral research funding for Tom to pursue “Understanding the Achilles’ heel of photosynthesis to improve global crop yields”.
BCFN students Fabiola Cardoso Delgado and Teo Garcia Millan are continuing for their PhD studies in the Oliver group after 6 month extended projects. Fabiola and Teo are jointly supervised by Dr. Heather Whitney and Prof. Carmen Galan, respectively.
EPSRC have funded an early career equipment grant application that will benefit many ECRs at the University of Bristol, including the Oliver group.
The funding will be used for the purchase of an ultrafast mid-infrared detector system for use in multidimensional optical spectroscopic measurements.
Professor Stephen Bradforth (University of Southern California, USA) will be visiting Bristol as a Benjamin Meaker Visiting Professor to collaborate with the Oliver group during September. Steve is an expert in DNA photodamage/protection and solar energy conversion, studying these phenomena with ultrafast spectroscopic techniques.
Our paper entitled “Surface functionalisation significantly changes the physical and electronic properties of carbon nano-dots” has been accepted in the journal Nanoscale. Working jointly with the Galan group and researchers in Chemistry and Physics at the University of Bristol, we used an arsenal of analytical and spectroscopic techniques to explore the physical and electronic structure of a variety of glycan functionalised carbon nano-dots. Carbon nano-dots are emerging as non-toxic fluorescent nanoparticles useful for biological applications such as targeting cancer cells or fluorescent labelling. Our studies reveal, counter to prior hypotheses, that the surface functionalisation does not always result in a homogenous corona surrounding the carbon dot core, and the choice of carbohydrate significantly affects the electronic structure of the surface CD states. The article can be found here.